Publications | Olena Morozova Vaske Lab

Framework for determining accuracy of RNA sequencing data for gene expression profiling of single samples

by yavasque | Oct 24, 2019 | Publications

Background The clinical value of identifying aberrant gene expression in tumors is becoming increasingly evident. In order for multi-gene expression analysis to achieve wider adoption and eventually be developed as a Clinical Laboratory Improvement Amendments...

Comparative RNA-Sequencing analysis benefits a pediatric patient with relapsed cancer.

by yavasque | Oct 24, 2019 | Publications

Clinical detection of sequence and structural variants in known cancer genes points to viable treatment options for a minority of children with cancer. To increase the number of children who benefit from genomic profiling, gene expression information must be...

Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor

by yavasque | Oct 24, 2019 | Publications

Gliomatosis peritonei is a rare pathologic finding that is associated with ovarian teratomas and malignant mixed germ cell tumors. The occurrence of gliomatosis as a ma- ture glial implant can impart an improved prognosis to patients with immature ovarian ter- atoma,...

Data sharing for clinical utility

by yavasque | Oct 24, 2019 | Publications

Genomic data offer valuable insights that can be used to help find treatments and cures for disease. Precision medicine, defined by the NIH as “an emerging approach for disease treatment and prevention that takes into account individual variability in genes,...